Classification of Anti Malarial Drugs

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Anti malarial drugs may be classified based on mechanism of action, therapeutic uses and chemistry.

Classification Based on Mechanism of Action

Causal prophylactics (drugs that kill the pre-erythrocytic forms of parasite)

  • Pyrimethamine
  • Primaquine
  • Proguanil

Clinical curatives (blood schizontocides)

Radical curtives (tissue schizontocides) (for p. Vivax & p. Ovale)

  • Primaquine

Gametocidal drugs (drugs that kill gametes and prevent spread of disease in mosquito)
a. For p. Vivax: chloroquine, quinine
b. For p. Falciparum: primaquine

Sporontocides: (drugs that inhibit the life cycle of malarial parasite in mosquitoes)

  • Primaquine
  • Chloroguanide

Classification Based on Chemistry

4-Aminoquinolines

8-Aminoquinoline

  • Primaquine

4-Quinoline- Methanol

Quinoline-containing Cinchona Alkaloids

  • Quinine
  • Quinidine

Diaminopyrimidine

  • Pyrimethamine

Sulfonamides/Sulfone

  • Sulfadoxine
  • Sulfalene
  • Dapsone

Sesquiterpene-Lactone

Phenanthrene-Methanol

  • Lumefantrine

Tetracyclines

  • Tetracycline
  • Doxycycline
  • Minocycline

Biguanides

  • Proguanil
  • Chlorproguanil
  • Cycloguanil

Hydroxy-naphthoquinone